Pathophysiology of acute coronary 1-syndromes.

cular Cell Adhesion Molecule-1 (VCAM-1), mediating a more sustained leukocyte adhesion to the endothelium. Chemokines attract monocytes and lymphocytes to the area allowing for their subsequent interaction with the endothelial adhesion molecules. Monocytes migrate between the endothelial cells and in response to a variety of chemical factors, mature into macrophages and express “scavenger receptors” on their surface. These macrophages ingest the modified LDL and become foam cells. The foam cells, and to a lesser extent T-lymphocytes, form the “fatty streak”, the earliest form of atherosclerotic plaque.